Read Secondary Schizophrenia Online
Authors: Perminder S. Sachdev
238
Chapter 17 – Mitochondrial disorders and psychosis
References
and DiMauro S.,
et al.
(Eds.).
19. Iizuka T., Sakai F. Pathogenesis of
Philadelphia: Butterworth
strokelike episodes in MELAS:
1. Schon E. A. (2003). The
Heinemann.
analysis of neurovascular cellular
mitochondrial genome. In The
mechanisms. Curr Neurovasc Res,
Molecular and Genetic Basis of
10. Goldstein J. M., Faraone S. V.,
2005.
2
(1):29–45.
Neurologic and Psychiatric
Chen W. J.,
et al.
Sex differences in
Disease, Rosenberg R. N.,
the familial transmission of
20. Scaglia F., Northrop J. L. The
Prusiner S. B. and DiMauro S.,
schizophrenia. Br J Psychiatry,
mitochondrial myopathy
et al.
(Eds.). Philadelphia:
1990.
156
:819–26.
encephalopathy, lactic acidosis
Butterworth Heinemann.
11. Shimizu A., Kurachi M.,
with strokelike episodes
(MELAS) syndrome – a review of
2. Chinnery P. F., Schon E. A.
Yamaguchi N.,
et al.
Morbidity
treatment options. CNS Drugs,
Mitochondria. J Neurol Neurosurg
risk of schizophrenia to parents
2006.
20
(6):443–64.
Psychiatry, 2003.
74
:1188–99.
and siblings of schizophrenic
patients. Jap J Psychiatr Neurol,
21. Kovacs G. G., Hoftberger R.,
3. Giles R. E., Blanc H., Cann H. M.,
1987.
41
(1):65–70.
Majtenyi K.,
et al.
Neuropathology
et al.
Maternal inheritance of
of white matter disease in
human mitochondrial-DNA. Proc
12. Whatley S. A., Curti D.,
Leber’s hereditary optic
Natl Acad Sci USA, 1980.
77
(11):
Marchbanks R. M. Mitochondrial
neuropathy. Brain, 2005.
6715–19.
involvement in schizophrenia and
other functional psychoses.
128
(Pt 1):35–41.
4. Sutovsky P., Moreno, R. D.,
Neurochem Res, 1996.
21
(9):
22. Fattal O., Budur K., Vaughan A. J.,
Ramalho-Santos J.,
et al.
995–1004.
et al.
Review of the literature on
Development – Ubiquitin tag for
13. Cavelier L., Jazin E. E., Eriksson I.,
major mental disorders in adult
sperm mitochondria. Nature,
et al.
Decreased cytochrome-c
patients with mitochondrial
1999.
402
(6760):371–2.
oxidase activity and lack of
diseases. Psychosomatics, 2006.
5. Finsterer J. Central nervous
age-related accumulation of
47
(1):1–7.
system manifestations of
mitochondrial DNA deletions in
23. Mizukami K., Sasaki M., Suzuki
mitochondrial disorders. Acta
the brains of schizophrenics.
T.,
et al.
Central nervous system
Neurol Scand, 2006.
114
:
Genomics, 1995.
29
(1):217–24.
changes in mitochondrial
217–38.
14. King L., Roberts R. C.
encephalomyopathy: light and
6. Chinnery P. E., Howell N.,
Mitochondrial pathology in
electron microscopic study. Acta
Lightowlers R. N.,
et al.
MELAS
human schizophrenic striatum: a
Neuropathol (Berl), 1992.
and MERRF – The relationship
postmortem ultrastructural study.
83
(4):449–52.
between maternal mutation load
Synapse, 1999.
31
(1):67–75.
24. Suzuki T., Koizumi J., Shiraishi
and the frequency of clinically
15. Martorell L., Segues T., Folch G.,
H.,
et al.
Psychiatric disturbance
affected offspring. Brain, 1998.
et al.
New variants in the
in mitochondrial
121
:1889–94.
mitochondrial genomes of
encephalomyopathy. J Neurol
7. DiMauro S. E. B. (2003).
schizophrenic patients. Eur J Hum
Neurosurg Psychiatry, 1989.
Mitochondrial disorders due to
Genet, 2006.
14
(5):520–8.
52
(7):920–2.
mutations in the mitochondrial
16. Odawara M., Arinami T., Tachi Y.,
25. Suzuki Y., Taniyama M.,
genome. In The Molecular and
et al.
Absence of association
Muramatsu T.,
et al.
Diabetes
Genetic Basis of Neurologic and
between a mitochondrial DNA
mellitus associated with 3243
Psychiatric Disease, Rosenberg R.
mutation at nucleotide position
mitochondrial tRNA(Leu(UUR))
N., Prusiner S. B., and DiMauro
3243 and schizophrenia in
mutation: clinical features and
S.,
et al.
(Eds.). Philadelphia:
Japanese. Hum Genet, 1998.
coenzyme Q10 treatment. Mol
Butterworth Heinemann.
102
(6):708–9.
Aspects Med, 1997.
18
(Suppl):
8. Servidei S. Mitochondrial
17. Janssen R., Nijtmans L. G., Van
S181–8.
encephalomyopathies:gene
Den Heuvel L. P.,
et al.
26. Yamazaki M., Igarashi H.,
mutation. Neuromusc Disord:
Mitochondrial complex I:
Hamamoto M.,
et al.
A case of
NMD, 2002.
12
(5):524.
structure, function and pathology.
mitochondrial
9. Hirano M. (2003). Mitochondrial
J Inherit Metab Dis, 2006.
29
(4):
encephalomyopathy with
disorders due to mutations in the
499–515.
schizophrenic psychosis,
nuclear genome. In The Molecular
18. Abe K. Cerebral lactic acidosis
dementia and neuroleptic
and Genetic Basis of Neurologic
correlates with neurological
malignant syndrome. Rinsho
and Psychiatric Disease,
impairment in MELAS.
Shinkeigaku, 1991.
31
(11):
239
Rosenberg R. N., Prusiner S. B.,
Neurology, 2004.
63
(12):2458.
1219–23.
Organic Syndromes of Schizophrenia – Section 3
27. Jaksch M., Lochmuller H.,
Neurosurg Psychiatry, 1998.
40. Domenech E., Gomez-Zaera M.,
Schmitt F.,
et al.
A mutation in mt
64
(5):692–3.
Nunes V. Wolfram/DIDMOAD
tRNALeu(UUR) causing a
34. Odawara M., Isaka M., Tada K.,
syndrome, a heterogenic and
neuropsychiatric syndrome with
et al.
Diabetes mellitus associated
molecularly complex
depression and cataract.
with mitochondrial myopathy and
neurodegenerative disease.
Neurology, 2001.
57
(10):
schizophrenia: a possible link
Pediatr Endocrinol Rev, 2006.
1930.
between diabetes mellitus and
3
(3):249–57.
28. Amemiya S., Hamamoto M., Goto
schizophrenia. Diabet Med, 1997.
41. Barrientos A., Volpini V.,
Y.,
et al.
Psychosis and progressing
14
(6):503.
Casademont J.,
et al.
A nuclear
dementia: presenting features of a
35. Kaido M., Fujimura H., Soga F.,
defect in the 4p16 region
mitochondriopathy. Neurology,
et al.
Alzheimer-type pathology in
predisposes to multiple
2000.
55
(4):600–1.
a patient with mitochondrial
mitochondrial DNA deletions in
29. Inagaki T., Ishino H., Seno H.,
myopathy, encephalopathy, lactic
families with Wolfram syndrome.
et al.
Psychiatric symptoms in a
acidosis and strokelike episodes
J Clin Invest, 1996.
97
(7):1570–6.
patient with diabetes mellitus
(MELAS). Acta Neuropathol
42. Swift R. G., Perkins D. O., Chase
associated with point mutation in
(Berl), 1996.
92
(3):312–8.
C. L.,
et al.
Psychiatric disorders
mitochondrial DNA. Biol
36. Apostolova L. G., White M.,
in 36 families with Wolfram
Psychiatry, 1997.
42
(11):1067–9.
Moore S. A.,
et al.
Deep white
syndrome. Am J Psychiatry, 1991.
30. Prayson R. A., Wang N.
matter pathologic features in
148
(6):775–9.
Mitochondrial myopathy,
watershed regions: a novel pattern
43. Shinkai T., Nakashima M.,
encephalopathy, lactic acidosis,
of central nervous system
Ohmori O.,
et al.
Coenzyme Q10
and strokelike episodes (MELAS)
involvement in MELAS. Arch
improves psychiatric symptoms in
syndrome: an autopsy report.
Neurol, 2005.
62
(7):
adult-onset mitochondrial
Arch Pathol Lab Med, 1998.
1154–6.
myopathy, encephalopathy, lactic
122
(11):978–81.
37. Campos Y., Garcia A., Eiris J.,
acidosis and strokelike episodes:
31. Spellberg B., Carroll R. M.,
et al.
Mitochondrial myopathy,
a case report. Aust NZ J
Robinson E.,
et al.
mtDNA disease
cardiomyopathy and psychiatric
Psychiatry, 2000.
34
:1034–5.
in the primary care setting. Arch
illness in a Spanish family
44. Lambert T. J., Velakoulis D.,
Intern Med, 2001.
161
(20):
harbouring the mtDNA 3303C >
Pantelis C. Medical comorbidity
2497–500.
T mutation. J Inherit Metab Dis,
in schizophrenia. Med J Aust,
32. Saijo T, Naito E, Ito M,
et al.
2001.
24
(6):685–7.
2003. 178 Suppl:S67–70.
Therapeutic effect of sodium
38. Ueda Y., Ando A., Nagata T.,
et al.
45. Fendri C., Mechri A., Khiari G.,
dichloroacetate on visual and
A boy with mitochondrial disease:
et al.
Oxidative stress involvement
auditory hallucinations in a
asymptomatic proteinuria without
in schizophrenia
patient with MELAS.
neuromyopathy. Pediatr Nephrol,
pathophysiology: a review.
Neuropediatrics, 1991.
2004.
19
(1):107–10.
Encephale, 2006.
32
(2 Pt
22
(3):166–7.
39. Polymeropoulos M. H., Swift R.
1):244–52.
33. Thomeer E. C., Verhoeven W. M.
G., Swift M. Linkage of the gene
46. Szeto H. H. Mitochondria-
A., Van De Vlasakker C. J. W.,
for Wolfram syndrome to markers
targeted peptide antioxidants:
et al.
Psychiatric symptoms in
on the short arm of chromosome
novel neuroprotective agents.
MELAS; a case report. J Neurol
4. Nat Genet, 1994.
8
(1):95–7.
AAPS J, 2006.
8
(3):E521–31.
240
Section 3
Organic syndromes of schizophrenia: other neurological disorders
Patricia I. Rosebush, Rebecca Anglin, and Michael Mazurek
Facts box
cortical interactions? In this case, one might expect the
r
result to be a disturbance of mental function. In other
Inherited leukodystrophies are under
words, a leukodystrophy that targets the white mat-recognized and under diagnosed in
ter of the brain will tend to produce psychiatric symp-psychiatric populations.