Read Secondary Schizophrenia Online
Authors: Perminder S. Sachdev
reports are available on the use of cholinesterase
Additionally, the efficacy and risks of neurophar-
inhibitors or memantine in FS or FD.
macologic and psychopharmacologic interventions in
For neurological symptoms, physiotherapy and
FD and the correlates of good and poor outcomes with
rehabilitation may be helpful. The response of parkin-these interventions remain to be defined
[11].
Given
sonian features to levodopa therapy is generally poor,
the substantial number of conditions associated with
possibly because the parkinsonism arises from post-
BGC, it is likely that more conditions will be identified
synaptic receptor site dysfunction and not decreased
in the future. The importance of distinguishing chance
dopamine turnover
[8].
A positive response to lev-associations from causal relationships should not be
odopa in limited cases has been attributed to the coex-underestimated. Future research may determine which
istence of IBGC and idiopathic Parkinson’s Disease
of these conditions cause FD
[2].
362
Chapter 29 – Fahr’s Disease and psychosis
References
10. Vles J. S. H., Lodder J., Van Der
19. Koller W. C., Cochran J. W.,
Lugt P. J. M. Clinical significance
Klawans H. L. Calcification of the
1. Manyam B. V., Walters A. S.,
of basal ganglia calcifications
basal ganglia: computerized
Narla K. R. Bilateral
detected by CT: A retrospective
tomography and clinical
striopallidodentate calcinosis:
study of 33 cases. Clin Neurol
correlation. Neurology, 1979.
clinical characteristics of patients
Neurosurg, 1981.
83
(4):253–6.
29
(3):328–33.
seen in a registry. Movement
Disord, 2001.
16
(2):258–64.
11. Lauterbach E. C., Cummings J. L.,
20. Pierri J. N., Lewis D. A. (2005).
Duffy J.,
et al.
Neuropsychiatric
Functional neuroanatomy. In
2. Lauterbach E. C. (2000). Fahr’s
correlates and treatment of
Kaplan and Sadock’s
syndrome. In Psychiatric
lenticulostriatal diseases: a review
Comprehensive Textbook of
Management in Neurological
of the literature and overview of
Psychiatry, Sadock B. J. and
Disease, Lauterbach E. C. (Ed.).
research opportunities in
Sadock V. A. (Eds.). Philadelphia:
Washington, DC: American
Huntington’s, Wilson’s, and Fahr’s
Lippincott Williams & Wilkins.
Psychiatric Publishing, Inc.,
diseases. A report of the ANPA
pp. 137–78.
21. Cummings J. L., Benson D. F.
Committee on Research.
Subcortical dementia. Review of
3. Manyam B. V. What is and what is
American Neuropsychiatric
an emerging concept. Arch
not ‘Fahr’s disease.’ Parkinsonism
Association. [See comment.]
Neurol, 1984.
41
(8):874–9.
Relat Disord, 2005.
11
(2):73–80.
J Neuropsych Clin Neurosci, 1998.
10
(3):249–66.
22. Bhimani S., Sarwar M.,
4. Chabot B., Roulland C., Dollfus S.
Virapongse C.,
et al.
Computed
Schizophrenia and familial
12. Harrington M. G., Macpherson P.,
tomography of cerebrovascular
idiopathic basal ganglia
McIntosh W. B.,
et al.
The
calcifications in postsurgical
calcification: a case report. Psychol
significance of the incidental
hypoparathyroidism. J Comput
Med, 2001.
31
(4):741–7.
finding of basal ganglia
Assist Tomogr, 1985.
9
(1):
calcification on computed
5. Brodaty H. M. P., Luscombe G.,
121–4.
tomography. J Neurol Neurosurg
Kwok J. B.,
et al.
Familial
Psychiatry, 1981.
44
(12):1168–70.
23. Sarwar M., Ford K. Rapid
idiopathic basal ganglia
development of basal ganglia
calcification (Fahr’s disease)
13. Kazis A. D. Contribution of CT
calcification. AJNR: Am J
without neurological, cognitive
scan to the diagnosis of Fahr’s
Neuroradiol, 1981.
2
(1):
and psychiatric symptoms is not
syndrome. Acta Neurol Scand,
103–4.
linked to the BGC1 locus on
1985.
71
(3):206–11.
24. Schultz W., Tremblay L.,
chromosome 14q. Hum Genet,
14. Konig P. Psychopathological
Hollerman J. R. Reward
2002.
110
:8–14.
alterations in cases of symmetrical
prediction in primate basal
6. Cohen C. R., Duchesneau P. M.,
basal ganglia sclerosis. Biol
ganglia and frontal cortex.
Weinstein M. A. Calcification of
Psychiatry, 1989.
25
(4):459–68.
Neuropharmacology, 1998.
the basal ganglia as visualized by
15. Murphy M. J. Clinical correlations
37
(4–5):421–9.
computed tomography. Radiology,
of CT scan-detected calcifications
25. Shakibai S., Johnson J., Bourgeois
1980.
134
(1):97–9.
of the basal ganglia. Ann Neurol,
J. Paranoid delusions and
7. Cummings J. L., Gosenfeld L. F.,
1979.
6
(6):507–11.
cognitive impairment suggesting
Houlihan J. P.,
et al.
16. Stellamor K., Stellamor V.
Fahr’s disease. Psychosomatics,
Neuropsychiatric disturbances
Roentgen diagnosis of Fahr’s
2005.
46
(6):569–72.
associated with idiopathic
disease. Rontgen-Blatter, 1983.
26. Aarsland D., Litvan I., Larsen J. P.
calcification of the basal ganglia.
36
(6):194–6.
Neuropsychiatric symptoms of
Biol Psychiatry, 1983.
18
(5):
17. Kobari M., Nogawa S., Sugimoto
patients with progressive
591–601.
Y.,
et al.
Familial idiopathic brain
supranuclear palsy and
8. Klawans H. L., Lupton M., Simon
calcification with autosomal
Parkinson’s disease. J Neuropsych
L. Calcification of the basal
dominant inheritance. Neurology,
Clin Neurosci, 2001.
13
(1):
ganglia as a cause of
1997.
48
(3):645–9.
42–9.
levodopa-resistant parkinsonism.
18. Forstl H., Krumm B., Eden S.,
27. Manyam B. V., Bhatt M. H.,
Neurology, 1976.
26
(3):221–5.
et al.
Neurological disorders in
Moore W. D.,
et al.
Bilateral
9. Ring H. A., Serra-Mestres J.
166 patients with basal ganglia
stiopallidodentate calcinosis:
Neuropsychiatry of the basal
calcification: a statistical
cerebrospinal fluid, imaging, and
ganglia. J Neurol Neurosurg
evaluation. J Neurol, 1992.
electrophysiological studies. Ann
Psychiatry, 2002.
72
(1):12–21.
239
(1):36–8.
Neurol, 1992.
31
:379–84.
363
Organic Syndromes of Schizophrenia – Section 3
28. Ellie E., Julien J., Ferrer X.
Holland Publishing Company,
calcification of basal ganglia
Familial idiopathic
pp. 703–25.
pathways. Bio Psychiatry, 1994.
striopallidodentate calcifications.
37. Casanova M. F., Araque J. M.
35
(5):345–51.
Neurology, 1989.
39
(3):381–5.
Mineralization of the basal
46. Rosenberg D. R., Neylan T. C.,
29. Flint J., Goldstein L. H. Familial
ganglia: implications for
el-Alwar M.,
et al.
calcification of the basal ganglia: a
neuropsychiatry, pathology and
Neuropsychiatric symptoms
case report and review of the
neuroimaging. Psychiatry Res,
associated with idiopathic
literature. Psychol Med, 1992.
2003.
121
(1):59–87.
calcification of the basal ganglia.
22
(3):581–95.
38. Duckett S., Galle P., Escourolle R.,
J Nerv Ment Dis, 1991.
30. Smits M. G., Gabreels F. J.,
et al.
Presence of zinc, aluminum,
179
(1):48–9.
Thijssen H. O.,
et al.
Progressive
magnesium in striopalledodentate
47. Wodarz N., Becker T., Deckert J.
idiopathic striopallido-dentate
(SPD) calcifications (Fahr’s
Musical hallucinations associated
calcinosis (Fahr’s disease) with
disease): electron probe study.
with post-thyroidectomy
autosomal recessive inheritance.
Acta Neuropathol, 1977.
hypoparathyroidism and
Report of three siblings. Eur
38
(1):7–10.
symmetric basal ganglia
Neurol, 1983.
22
(1):58–64.
39. Smeyers-Verbeke J., Michotte Y.,
calcifications. [See comment.]
J Neurol Neurosurg Psychiatry,
31. Geschwind D. H., Loginov M.,
Pelsmaeckers J.,
et al.
The
1995.
58
(6):763–4.
Stern J. M. Identification of a
chemical composition of
locus on chromosome 14q for
idiopathic nonarteriosclerotic
48. Hall P. Calcification of the basal
idiopathic basal ganglia
cerebral calcifications. Neurology,
ganglia apparently presenting as a
calcification (Fahr disease). Am J
1975.
25
(1):48–57.
schizophreniform psychosis.
Hum Genet, 1999.
65
(3):764–72.
40. Bouras C., Giannakopoulos P.,
Postgrad Med J, 1972.
48
:636–9.
32. Lowenthal A. (1986).
Good P. F.,
et al.
A laser
49. Fernandez-Bouzas A., Angrist B.,
Striopallidodentate calcifications.
microprobe mass analysis of trace
Hemdal P.,
et al.
Basal ganglia
In Handbook of Clinical
elements in brain mineralizations
calcification in schizophrenia. Biol
Neurology, Vol 5(49), Vinken P. J.
and capillaries in Fahr’s disease.
Psychiatry, 1990.
27
(6):682–5.
and Bruyn G. W. (Eds.).
Acta Neuropathol, 1996.
50. Brodaty H., Mitchell P., Luscombe
Amsterdam: John Wiley & Sons,
92
(4):351–7.
G.,
et al.
Familial idiopathic basal
Inc., pp. 417–36.
41. Beall S. S., Patten B. M., Mallette
ganglia calcification (Fahr’s
33. Adachi M., Wellmann K. F., Volk
L.,
et al.
Abnormal systemic
disease) without neurological,
B. W. Histochemical studies on
metabolism of iron, porphyrin,
cognitive and psychiatric
the pathogenesis of “idiopathic
and calcium in Fahr’s syndrome.
symptoms is not linked to the
nonarteriosclerotic cerebral
Ann Neurol, 1989.
26
(4):569–75.
IBGC1 locus on chromosome
calcification.” J Neuropathol Exper
42. Kobayashi S., Yamadori I., Miki
14q. Hum Genet, 2002.
110
:8–14.
Neurol, 1968.
27
(1):153–4.
H.,
et al.
Idiopathic
51. Lopez-Villegas D., Kulisevsky J.,
34. Friede R. L., Magee K. R., Mack E.
nonarteriosclerotic cerebral
Deus J.,
et al.
Neuropsychological
W. Idiopathic nonarteriosclerotic
calcification (Fahr’s disease): an