The Dog Cancer Survival Guide (132 page)

MOPP chemotherapy for treatment of resistant lymphoma in dogs: a retrospective study of 117 cases (1989-2000). Rassnick KM, Mauldin GE, Al-Sarraf R et al.
J Vet Intern Med.
16(5):576- 8, 2002.

Efficacy of Maropitant in the Prevention of Delayed Vomiting Associated with Administration of Doxorubicin to Dogs. Rau S, Barber L, and Burgess K.
J Vet Intern Med
, 24: 1452–1457, 2010.

Tolerability of Metronomic Administration of Lomustine in Dogs with Cancer. Tripp C, Fidel J, Anderson C, et al.
J Vet Intern Med
, 25: 278–284, 2011.

Cimetidine

Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression. Kobayashi K, et al.
Cancer Res.
2000 Jul 15;60(14):3978-84.

Effect of histamine on the growth of human gastrointestinal tumours: reversal by cimetidine. Watson SA, et al.
Gut.
1993 Aug;34(8):1091-6.

Cimetidine inhibits in vivo growth of human colon cancer and reverses histamine stimulated in vitro and in vivo growth. Adams WJ, Lawson JA, Morris DL.
Gut
. 1994 Nov;35(11):1632- 6.

Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells. Matsumoto, S. et al.
Br J Cancer
. 2002 January 21; 86(2): 161–167.

Cimetidine in colorectal cancer--are the effects immunological or adhesion-mediated? Eaton D, Hawkins RE.
Br J Cancer
. 2002 Jan 21;86(2):159-60.

Characterization and development of cimetidine as a histamine H2-receptor antagonist. Brimblecombe RW, Duncan WA, Durant GJ, Emmett JC, Ganellin CR, Leslie GB, Parsons ME.
Gastroenterology.
1978 Feb;74(2 Pt 2):339-47.

Does cimetidine improve prospects for cancer patients? A reappraisal of the evidence to date. Siegers CP, Andresen S, Keogh JP.
Digestion
1999 Sep-Oct;60(5):415-21.

Evaluation of Cimetidine Treatment for Melanomas in Seven Horses. Preliminary Report 16 Refs. *Lorin D. Warnick, DVM, PhD, Mary E. Graham, DVM, and Beth A. Valentine, DVM, PhD.
Equine Pract
17[7]:16-22 Jul’95.

Cimetidine for the Treatment of Melanomas in Horses: Efficacy Determined by Client Questionnaire.
Equine Pract
16[5]:18- 21 May’94. Retrospective Study 12 Refs. *Jonathan E. Hare; Henry R. Staempfli.
Am J Clin Oncol
1991 Oct;14(5):397-9.

Phase II trial of cimetidine in metastatic melanoma. A Hoosier Oncology Group trial. Mandanas R, Schultz S, Scullin D, Einhorn LH.
J Am Vet Med Assoc
1990 Feb 1;196(3):449-52.

Cimetidine for treatment of melanomas in three horses. Goetz TE, Ogilvie GK, Keegan KG, Johnson PJ.
J Am Vet Med Assoc
. 1990 Feb 1;196(3):449-52.

Treatment of advanced malignant melanoma with coumarin and cimetidine: a pilot study. Marshall ME, Butler K, Cantrell J, Wiseman C, Mendelsohn L.
Cancer Chemother Pharmacol
1989;24(1):65-6.

Regression of melanoma nodules in a patient treated with ranitidine. Smith T, Clark JW, Popp MB.
Arch Intern Med
1987 Oct;147(10):1815-6.

Coenzyme Q10

Coenzyme q10 for prevention of anthracycline-induced cardiotoxicity. Conklin KA.
Integr Cancer Ther
. 2005 Jun;4(2):110- 30.

Adriamycin cardiotoxicity: early detection by systolic time interval and possible prevention by coenzyme Q10. Cortes EP, et al.
Cancer Treat Rep
. 1978 Jun;62(6):887-91.

[Investigation of the preventive effect of CoQ10 against the side-effects of anthracycline antineoplastic agents] Tsubaki K, et al.
Gan To Kagaku Ryoho.
1984 Jul;11(7):1420-7. [Article in Japanese]

[Chronic cardiotoxicity of anthracycline derivatives and possible prevention by coenzyme Q10] Tajima M.
Gan No Rinsho
. 1984 Jul;30(9 Suppl):1211-6. [Article in Japanese]

Cardioprotection against the toxic effects of anthracyclines given to children with cancer: a systematic review. Bryant J, et al.
Health Technol Assess
. 2007 Jul;11(27):iii, ix-x, 1-84. Review.

Effect of coenzyme Q10 on the disposition of doxorubicin in rats. Zhou Q, Chowbay B.
Eur J Drug Metab Pharmacokinet
. 2002 Jul-Sep;27(3):185-92.

Reduction by coenzyme Q10 of the acute toxicity of adriamycin in mice. Combs AB, et al.
Res Commun Chem Pathol Pharmacol
. 1977 Nov;18(3):565-8.

Effect of coenzyme Q10 on the survival time and lipid peroxidation of adriamycin (doxorubicin) treated mice. Shinozawa S, et al.
Acta Med Okayama
. 1984 Feb;38(1):57-63.

Protective effect of exogenous coenzyme Q against damage by adriamycin in perfused rat liver. Valls V, et al.
Biochem Mol Biol Int
. 1994 Jul;33(4):633-42.

Efficacy of coenzyme Q10 for improved tolerability of cancer treatments: a systematic review. Roffe L, Schmidt K, Ernst E.
J Clin Oncol.
2004 Nov 1;22(21):4418-24. Review.

Comparative cancer medicine: Dogs and Humans

Naturally occurring cancer in pet dogs: important models for developing improved cancer therapy for humans. Knapp DW and Waters DJ.
Mol Med Today
. 1997 Jan;3(1):8-11.

Spontaneously occurring tumors of companion animals as models for human cancer. Vail DM and MacEwen EG.
Cancer Invest
. 2000;18(8):781-92.

Using the canine genome to cure cancer and other diseases. Olson PN.
Theriogenology
. 2007 Aug;68(3):378-81.

Leading the way: canine models of genomics and disease. Shearin AL and Ostrander EA.
Dis Model Mech
. 2010 Jan- Feb;3(1-2):27-34.

Translation of new cancer treatments from pet dogs to humans. Paoloni M, Khanna C.
Nat Rev Cancer.
2008 Feb;8(2):147-56. Review.

Pet models in cancer research: general principles. Porrello A, Cardelli P, Spugnini EP.
J Exp Clin Cancer Res
. 2004 Jun;23(2):181-93.

Cordyceps sinensis (also see beta glucans for related citations)

Medicinal herbal extracts--renal friend or foe? Part two: herbal extracts with potential renal benefits. Wojcikowski K, Johnson DW, Gobé G.
Nephrology (Carlton).
2004 Dec;9(6):400-5.

Effects of Cordyceps sinensis on dimethylnitrosamine-induced liver fibrosis in rats. Li FH, Liu P, Xiong WG, Xu GF.
Zhong Xi Yi Jie He Xue Bao
. 2006 Sep;4(5):514-7. Chinese.

Cordyceps mycelia extract decreases portal hypertension in rats with dimethylnitrosamine-induced liver cirrhosis: a study on its histological basis. Wang XB, Liu P, Tang ZP, Li FH, Liu CH, Hu YY, Xu LM.
Zhong Xi Yi Jie He Xue Bao
. 2008 Nov;6(11):1136-44. Chinese.

Effects of cordyceps sinensi on bleomycin-induced pulmonary fibrosis in mice. Wang SJ, et al.
Zhongguo Zhong Yao Za Zhi.
2007 Dec;32(24):2623-7. Chinese.

Cordyceps sinensis extract suppresses hypoxia-induced proliferation of rat pulmonary artery smooth muscle cells. Gao BA, Yang J, Huang J, Cui XJ, Chen SX, Den HY, Xiang GM.
Saudi Med J
. 2010 Sep;31(9):974-9.

Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis, a Chinese herbal medicine. Liu WC, et al.
Radiat Res
. 2006 Dec;166(6):900-7.

Effect of Cordyceps sinesis on T-lymphocyte subsets in chronic renal failure. Guan YJ, Hu Z, Hou M.
Zhongguo Zhong Xi Yi Jie He Za Zhi.
1992 Jun;12(6):338-9, 323. Chinese.

Effects of Chinese medicinal fungus water extract on tumor metastasis and some parameters of immune function. Zhang W, Wang Y, Hou Y.
Int Immunopharmacol.
2004 Mar;4(3):461-8.

Cordyceps sinensis health supplement enhances recovery from taxol-induced leukopenia. Liu WC, et al.
Exp Biol Med
(Maywood). 2008 Apr;233(4):447-55.

Curcumin

Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway. Chirnomas D, et al.
Mol Cancer Ther
. 2006 Apr;5(4):952-61.

Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells. Kamat AM, Sethi G, Aggarwal BB.
Mol Cancer Ther
. 2007 Mar;6(3):1022-30.

Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factorkappaB-regulated gene products. Kunnumakkara AB, et al.
Cancer Res
. 2007 Apr 15;67(8):3853-61.

Possible benefits of curcumin regimen in combination with taxane chemotherapy for hormone-refractory prostate cancer treatment. Cabrespine-Faugeras A, et al.
Nutr Cancer
. 2010;62(2):148-53.

Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. Kunnumakkara AB, et al.
Int J Cancer
. 2009 Nov 1;125(9):2187-97.

Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells. Kamat AM, Sethi G, Aggarwal BB.
Mol Cancer Ther
. 2007 Mar;6(3):1022-30.

Curcumin prevents adriamycin nephrotoxicity in rats. Venkatesan N, Punithavathi D, Arumugam V,
Br J Pharmacol
. 2000 January; 129(2): 231–234.

Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids. Limtrakul P, Anuchapreeda S, Buddhasukh D.
BMC Cancer
. 2004 Apr 17;4:13.

Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells. Javvadi P, et al.
Cancer Res
. 2010 Mar 1;70(5):1941-50.

Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3. Chendil D, et al.
Oncogene
. 2004 Feb 26;23(8):1599- 607.

The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogenactivated protein kinase pathway. Javvadi P, et al.
Mol Pharmacol
. 2008 May;73(5):1491-501.

Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factorkappaB- regulated gene products. Kunnumakkara AB, et al.
Clin Cancer Res
. 2008 Apr 1;14(7):2128-36.

Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines. Okunieff P, et al.
Int J Radiat Oncol Biol Phys
. 2006 Jul 1;65(3):890-8.

Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Sharma RA, et al.
Clin Cancer Res
. 2004 Oct 15;10(20):6847-54.

Phase II trial of curcumin in patients with advanced pancreatic cancer. Dhillon N, et al.
Clin Cancer Res
. 2008 Jul 15;14(14):4491-9.

Curcumin acts as anti-tumorigenic and hormone-suppressive agent in murine and human pituitary tumour cells in vitro and in vivo. Schaaf C, et al.
Endocr Relat Cancer
. 2009 Dec;16(4):1339-50.

Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway. Lin YG, et al.
Clin Cancer Res
. 2007 Jun 1;13(11):3423-30.

Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Dorai T, et al.
Prostate
. 2001 Jun 1;47(4):293-303.

Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth. Gururajan M, et al.
J Immunol
. 2007 Jan 1;178(1):111-21.

Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis. Shankar S, et al.
Mol Cancer
. 2008 Jan 29;7:16.

Curcumin: the story so far. Sharma RA, Gescher AJ, Steward WP.
Eur J Cancer
. 2005 Sep;41(13):1955-68.

Bioavailability of curcumin: problems and promises. Anand P, et al.
Mol Pharm
. 2007 Nov-Dec;4(6):807-18.

Induction of apoptosis by curcumin and its implications for cancer therapy. Karunagaran D, Rashmi R, Kumar TR.
Curr Cancer Drug Targets
. 2005 Mar;5(2):117-29.